Most clinical trials of GLP-1 medications (such as Wegovy and Mounjaro) have not shown a significant increase in mental health issues such as depression, anxiety, or suicidal thoughts.
However, some recent studies suggest there may be a small risk of mood changes in certain patients, while other research shows GLP-1 medications could actually help improve symptoms of depression and anxiety over time.
Overall, the evidence is mixed, and more research is needed. We recommend that all patients monitor their mental health closely while using these treatments.
What to do if you notice mood changes
- Please reach out to your GP, specialist, or a mental health professional for advice.
- You can also submit a request, we can arrange a review with your Prescriber.
When to seek urgent help
Stop taking your medication immediately and seek urgent medical support if you experience:
- Thoughts of suicide or self-harm
- Severe mood changes
In an emergency:
- Call 999 or attend your nearest Accident and Emergency Department (A&E).
You can also access free support through NHS urgent mental health helplines. Visit the NHS mental health support page.
Help is available, and early support can make a significant difference. Please don't hesitate to reach out if you need help at any time.